Job Description
Job Description: Job Description Principal Scientist - US, Lenexa, Kansas (KS)- LBA Method Development Team ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster. As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers. Are you a scientist with expertise in method development? Take the next step in your career by joining ICON where you'll advance groundbreaking clinical therapies by leading global client programs. We are excited to be seeking a new Principal Scientist at ICON in Lenexa, Kansas (KS). The Principal Scientist will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities. We are seeking candidates with robust method development and knowledge in science for new biological modalities. What You Will Do This Research Scientist is responsible for method development and validation testing using complex ligand-binding analytical methods. In addition, you will oversee transfer of LBA methods for large molecules for further bioanalytical testing. Desired Experience (ligand binding experience required)Ligand binding assays ELISA, ECLIAPK, PD, and immunogenicityUsage of relevant software (e.g. SoftMax Pro, Watson, or equivalent)Neutralizing antibody or Flow Cytometry experience is beneficial. Method DevelopmentDesigns and executes experiments for method development under supervision or independently depending on levelDevelops new scientific approaches to method development and communicates these to the global science teamDepending on level the scientist may: Mentor more junior scientists and advise operation on developed methodsReviews and approves data of other scientistsCommunicate with team members and management regarding project status, purpose, scheduling, problems, etc.Communicate and/or participate in communication with clients regarding project status. ScientificMaintain knowledge and skill in all techniques where you perform your work.Provide scientific input to management and BD about new technology investments and lines of service.Discusses scientific results with sponsors together with project managerPromotes ICON utilizing their scientific skills through scientific communication such as external publication of posters and journal articles.Perform R&D projectsTraining of technicians on technical aspectsMentor and train staff on scientific topics Quality and Timely Work ExecutionTakes initiative in process development and SOP/WI writingLegible, logical and reproducible documentation of all experimentationHas a thorough understanding and complies with GLP and other appropriate regulationsDevelops rugged and economical assaysPerforms data review of other scientist's work Sample Analysis and Assay ValidationProvides key assay input to the validation and bioanalysis team(s) to ensure successful executionAssay troubleshootingMay perform and document maintenance, troubleshooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel. Qualifications Read, write and speak fluent English.BS in a scientific discipline required. Advanced degree (MS or PhD), preferred.5 - 10 years of industry or academic laboratory experience supporting ligand-binding assays.Demonstrated method development experience within the clinical or pharmaceutical industry with a track record of managing scientific projects.Presenter/Publisher in Regulated relevant field, nice to have. Employment with ICON is contingent upon having the legal right to work in the country where the role is based. Rewards & Benefits ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development. Benefits may include:Competitive base salary and performance related incentivesHealth and wellbeing programmes including medical, dental, and vision coverage where applicableRetirement and pension plansLife assurance and disability coverageEmployee assistance programmes and wellbeing resourcesLearning and development opportunities through structured training and career pathways Benefits may vary depending on role and location. Visit our careers site to read more about the benefits ICON offers. Inclusion and Accessibility ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported. If you require reasonable accommodations during the recruitment process, please let us know or submit a request here. Are you a current ICON Employee? Please click here to apply